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“Our purpose is to comprehend woman reproductive growing old, and why fertility promptly declines starting within the mid-30s,” suggests Satoshi Namekawa, a professor of Microbiology and Molecular Genetics, in whose lab Munakata performs.

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Namekawa thinks that in human oocytes, alterations in these patterns could disrupt the sensitive choreography of genes becoming turned on and off at the right instances — leaving them unprepared for fertilization or growth into nutritious embryos. Modifications in chromatin composition as an oocyte ages may additionally impact the best way that chromosomes segregate during cell division.

This protein might “create and preserve the chromatin condition,” suggests Namekawa — maintaining the spools in position and the oocytes genetically primed as the mouse matures.

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